Papers that Summarize and Compare Medication Options

• International Veterinary Epilepsy Task Force consensus proposal: medical treatment of canine epilepsy in Europe. https://pmc.ncbi.nlm.nih.gov/articles/PMC4552371/?utm

• Treatment in canine epilepsy - a systematic review (found oral phenobarbital and imepitoin in particular, as well as potassium bromide and levetiracetam are likely to be effective for the treatment of IE) https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-014-0257-9?utm

IMEPITOIN (PEXION)

• Clinical efficacy and safety of imepitoin in comparison with phenobarbital for the control of idiopathic epilepsy in dogs. (This study found Imepitoin matched phenobarbital in efficacy with fewer side effects in a 226‑dog blinded trial) https://pubmed.ncbi.nlm.nih.gov/25079881/

• Clinical evaluation of a combination therapy of imepitoin with phenobarbital in dogs with refractory idiopathic epilepsy. (This study found that a combination treatment of imepitoin and phenobarbital is a useful treatment option for a subpopulation of dogs with drug-resistant epilepsy) https://pubmed.ncbi.nlm.nih.gov/28118828/