Levetiracetam (Keppra) for Dogs with Seizures

When Ruby’s seizures became more frequent, our vet suggested adding a medication called levetiracetam (better known by the brand name Keppra) to her treatment plan. I’ve learned how it works, what to expect, and how to support a dog on this medicine. In today’s post, I want to share what I discovered so you can feel more confident if your veterinarian brings up Keppra for your dog.

What Is Levetiracetam & Why It’s Used

Levetiracetam is an antiepileptic drug commonly used in dogs to help control seizures either by itself or alongside other medications. One of the reasons many vets like Keppra is that it is processed mostly by the kidneys rather than the liver. That means it tends to have fewer interactions with other drugs that stress the liver. Because of these properties, levetiracetam can be especially useful in dogs who have had liver issues or are taking other medications that affect the liver.

How It’s Usually Given & Dosage

Keppra (levetiracetam) can be administered to dogs orally via tablets or liquid solution, or by injection. The specific method, dosage, and frequency are determined by a veterinarian based on the dog's weight, condition, and response to treatment. One thing to stress: do not abruptly stop levetiracetam. Stopping suddenly can cause seizures to return or worsen.

Possible Side Effects & What to Watch

The most common side effects of levetiracetam in dogs are drowsiness, a wobbly gait, and gastrointestinal issues such as vomiting or diarrhea. Side effects are generally uncommon, and many dogs tolerate the medication well. If you notice troublesome side effects or a sudden change in your dog’s seizure pattern, contact your vet right away.

Learn More About Caring for a Dog with Epilepsy

If you’re feeling overwhelmed trying to manage medications, track seizures, and keep your dog safe, you’re not alone. I’ve been there, and that’s exactly why I created my online course, My Dog Was Diagnosed With Epilepsy – Now What?

In the course, you’ll learn step-by-step how to:

  • Build a reliable medication and tracking routine

  • Handle seizures calmly and confidently

  • Save money on prescriptions and vet care

  • Understand what to expect as you care for your dog long-term

Click here to learn more!

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Phenobarbital and Dog Seizures

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How to Monitor Your Dog With Seizures While You Are Away